Three young doctors Lily Brenner, Mina Minard and Tommy Fuller arrive in a small town in the South American jungle to work in a understaffed, under-stocked medical clinic. They meet the legendary and enigmatic Dr. Ben Keeton , who was the youngest Chief of Surgery at UCLA but resigned and founded the clinic in the middle of nowhere. They're also introduced to the rest of the team – doctors Otis Cole, Ryan Clark and local doctor Zita Alvarez. The newcomers have to learn to work in this new, challenging environment.