The ER adjusts to the new department head who questions Rorish's decisions. An ambulance arrives with its paramedics knocked out by their patient, who attacks Jesse. Later, Jesse has a heart attack. As the doctors try to save him, other patients include a man hit by a train, the daughter of a controlling Beverly Hills mother, and the wife of a veteran who is struggling with addiction. Meanwhile, Mario leaves the hospital to find the train victim's son with intellectual disabilities, against Hudson's orders.